Can You Take Tramadol and Oxycodone Together?

Can You Take Tramadol and Oxycodone Together?

Prescription opioids are used to treat mild to severe pain. There are numerous types of opioids that range in strength and dose, and each is prescribed depending on their strengths, the severity of the person’s symptoms, and more. Some opioids are also prescribed together to treat patients who have severe pain or are intolerant to other medications. In light of this, today, we’re looking into whether you can take tramadol and oxycodone together.


Tramadol vs. Oxycodone: What Are They?

Although tramadol and oxycodone are both opioids, their chemical structure is very different. This affects their potency and potential for addiction. One of the main differences between oxycodone and tramadol is that oxycodone is 1.5 times more potent than morphine, while tramadol is only 10% as strong as morphine. This means that oxycodone is much stronger.


Due to these differences in potency, oxycodone is categorized as a Schedule II drug, while tramadol is scheduled as a Schedule IV drug. So, while both substances are addictive, oxycodone has a higher potential for abuse and addiction.


With that said, because both drugs are opioids, they produce similar side effects, simply at differing levels of intensity. Oxycodone also tends to kick in much quicker than tramadol, which lends to its addictive qualities.


Opioids bind themselves to opioid receptors in the brain and other areas of the body to block pain signaling. In addition to alleviating any painful symptoms, opioids also stimulate the release of dopamine, the brain’s “feel-good” chemical. A sense of euphoria and well-being occurs as a result, producing a high.


The higher the dose, the stronger the high. Opioids’ effects on dopamine and reward in the brain make up the drug’s addictive nature. When dopamine floods the brain, the reward system is also activated, encouraging further drug-taking behavior.


Both oxycodone and tramadol also lead to physical dependence, which can escalate to addiction without guidance and monitoring from a doctor. Physical opioid dependence usually occurs in patients who take these medications for long periods.


Physical dependence becomes apparent when the person experiences withdrawal symptoms when they aren’t taking the drug. Opioid withdrawals can be highly uncomfortable, so much so that patients will take opioids simply to avoid them.


Physical dependence is also marked by increased tolerance. This occurs when a person requires more of a drug to experience the same effects. Without proper supervision from a doctor, this can lead to a dangerous cycle of drug misuse.


Can You Take Tramadol With Oxycodone?

Because oxycodone is so much more potent than tramadol, they’re rarely prescribed together. Conversely, because tramadol is a weaker opioid, it wouldn’t offer many benefits if it were taken with oxycodone. However, this is not to say that there aren’t risks of combining the two.


Taking oxycodone and tramadol together without the guidance or supervision of a healthcare professional can be highly dangerous. When doctors prescribe opioids together, they do so carefully and according to the person’s body and symptoms. Unfortunately, people who have grown dependent on opioids and misuse them may attempt to combine them with other drugs of the same class for a stronger high.


Despite tramadol being a weaker opioid, taking it with oxycodone is not advised unless prescribed by a doctor. Taking tramadol with oxycodone can lead to a dangerous reaction, as well as side effects like:


  • Extreme sedation and drowsiness
  • Euphoria
  • Confusion
  • Dizziness
  • Difficulty concentrating
  • Impaired judgment
  • Impaired motor coordination
  • Unresponsiveness
  • Respiratory depression or difficulty breathing
  • Coma
  • Death


Because opioids depress the central nervous system, including functions like breathing and heart rate, taking higher doses than prescribed or mixing opioids without the consent of a doctor can increase their effects on the body. In the end, an oxycodone-tramadol interaction can lead to an opioid overdose, which is characterized by symptoms like breathing problems and slowed heart rate. Without medical assistance, a person experiencing an opioid overdose may lose consciousness from lack of oxygen, experience brain damage, and even die.


For this reason, it’s highly important to take prescription medications as prescribed and to avoid combining them with alcohol or other drugs unless directed by a doctor. The ongoing opioid epidemic is proof of how dangerous opioids like tramadol and oxycodone can be when they’re abused, so be sure to take your medications responsibly.


Help for Opioid Abuse

Opioids are potent drugs that are known for their euphoric and addictive side effects. Considering the rise in synthetic opioids and opioid-related overdose in the nation, it’s important now more than ever to look out for any signs of addiction. The good news is that help is available.


Our luxury drug and alcohol rehab in Palm Beach offers opioid and prescription drug addiction treatment that addresses both the physical and psychological factors of substance abuse. We understand how intensely these drugs can impact a person’s mind and body, so we are sure to include everything in patients’ programs, from medical treatment for withdrawals to therapy.


With the help of our medically assisted detox, we can help patients take that first step towards recovery without relapsing. During withdrawal treatment, our medical team offers round-the-clock care to ensure the safety and success of our patients.


You do not have to go through addiction recovery alone. Let us help. To learn how our high-end rehab in Florida can help you or a loved one achieve sobriety, reach out to us at 561-677-9374.


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